The blogmaster changed the title submitted – David, blogmaster

If your house was flooded with water, and the water level was rising, what would you do? The obvious solution would be to close the water faucet, and then start cleaning up.




If your house was flooded with water, and the water level was rising, what would you do? The obvious solution would be to close the water faucet, and then start cleaning up.

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The banks along with other financial institutions have already announced a 90 day moratorium on loans effective April 1st. There is no need to therfore contact them.
The readers may find the article below interesting, As I have said previously persons who are trained in the field for the most part are handling things. Some mistakes have been made, Matters should be left in the hands of those who are trained in the discipline
EXCLUSIVE: ‘Normal life won’t resume until 2021.’ Top scientist in pandemic preparedness says we won’t going back to our daily lives until there’s a coronavirus vaccine – which could take over a year
Ali Nouri, President of the Federation of American Scientists, told DailyMail.com that the public may not be ‘going back to our daily lives’ for another year
Nouri says normal life cannot resume until a vaccine against coronavirus is in circulation, which could take over a year to produce
He warns the the virus could resurge in several ways without a proper vaccine
‘There’s not going to be a time when there is a magic date and then everybody goes back to their lives as normal,’ he says
He says that the US is far from flattening the curve of coronavirus infections
By RYAN PARRY, WEST COAST EDITOR FOR DAILYMAIL.COM AND JOSH BOSWELL FOR DAILYMAIL.COM
PUBLISHED: 16:56 BST, 7 April 2020 | UPDATED: 19:54 BST, 7 April 2020
A top scientist and expert in pandemic preparedness and response has issued a stark warning to the American public: ‘Normal life won’t resume until 2021.’
Ali Nouri, President of the Federation of American Scientists, told DailyMail.com that the public may not be ‘going back to our daily lives’ until a vaccine against coronavirus is in circulation, which could take over a year.
Dr Nouri, an expert in virology, cell biology, and developmental biology, cautioned anyone hoping for social distancing or lockdown precautions to be dropped before summer that the virus was ‘unprecedented’ in living memory and could resurge in several waves.
‘We will certainly have to continue these stay at home orders for I suspect at least through the end of May, or perhaps some time in June,’ the leading scientist said.
‘There’s not going to be a time when there is a magic date and then everybody goes back to their lives as normal. That’s not going to happen for a long time.
‘Once June comes around, once July comes around, it’s not going to be the kind of situation where people are going to be going to crowded restaurants and movie theaters. Things are going to be different, I suspect, until we have the vaccine.’
Nouri said that the US is currently far from ‘flattening the curve’, a mantra of public health officials meaning reducing the rate of infection enough to keep hospitals from becoming overwhelmed.
He said even though the ground zero of the crisis, Wuhan, China, had cracked down hard on the virus and was several weeks further along in their containment process than the US, it was still enforcing some lockdown measures.
Despite reporting no new domestic cases of the virus, the Chinese government is still telling residents of the city to stay indoors where possible.’That really tells you that this virus has the potential to really flare up again, even in places that have flattened the curve,’ Nouri added.
‘If we do really do a good job of flattening that curve and reducing the number of transmissions from person to person, we still have to be very careful while we lift those restrictions.
‘What’s really different about this novel coronavirus is that it’s this combination of both being very contagious and then also at the same time being about 10 times more lethal than the flu.’
Current data suggests each person with coronavirus infects more than two others, on average.
More than 3,000 people died from the virus in Wuhan, a city of 11 million people, accounting for the majority of the deaths in mainland China.
A Lancet study published earlier this month by researchers at the London School of Hygiene and Tropical Medicine found that extending the lockdown through April could buy crucial time for hospitals and delay a second wave of infections from late August to October.
‘The city now needs to be really careful to avoid prematurely lifting physical-distancing measures, because that could lead to an earlier secondary peak in cases,’ said study co-author Kiesha Prem.
Nouri has been the head of the FAS since 2018, prior to that he served in Congress advising Senators Jim Webb and Al Franken for over a decade.
He served in various positions including as legislative director, national security advisor, energy and environment advisor, and as a science and technology advisor. He began his Senate career as a AAAS Congressional Science and Engineering Fellow.
Nouri is co-chair of the National Academies of Science, Engineering and Medicine’s New Voices initiative; serves on the upcoming National Academy’s Global Science Diplomacy Roundtable; and chairs the AAAS Science and Engineering Fellowship Advisory Committee.
He has also served as an advisor in the office of then UN Secretary General Kofi Annan, and as a research associate at Princeton University’s Woodrow Wilson School where he developed initiatives to bolster global health, while working to reduce the risk of deliberate biological weapon attacks.
He holds a B.A. in Biology from Reed College and a Ph.D. in Molecular Biology from Princeton University.
Dr Nouri, who has previously served in Congress advising Senators Jim Webb and Al Franken, said that to effectively tackle COVID-19, America needs to have far more widespread testing, not only to detect who has the virus but also who has since become immune.
‘The really challenging part of this is that the virus can be passed on asymptomatically. As high as 25% of infections turn out to be coming from people who don’t even know that they themselves are infected,’ the infectious disease
‘We need a lot more diagnostic testing. We need to really have a really good idea of the dynamics of the infection; who’s infected, who’s not infected. So when we actually do leave our homes, when we do identify new cases, we can quickly introduce mitigation measures again on areas that are impacted.
‘We’ll probably also need to expand serological tests where we can detect antibodies in individuals that already succumbed to the virus and have recovered and therefore are more likely to have a level of immunity that others may not have.’
The number of cases nationwide Monday shot to 368,254, with at least 11,000 dead, according to data compiled by John Hopkins University.
Dr Nouri warned against a ‘patchwork system’ where some states are stricter than others, which he blamed on indecision by the White House.
‘The White House is essentially saying ”we’re gonna leave it to you to decide”,’ he said.
‘In Virginia the governor has issued stay at home orders until June 10th which I think was the right thing to do, but in Florida you don’t have anything in place.
‘You could end up creating a patchwork system where some states are doing a better job than others. This is a global pandemic that doesn’t recognize those state lines. There has to be more uniformity across the board.’
@ Robert
You seem to love the Daily Mail.
For once I thank GP2. It is obvious that the epidemic is spreading only linearly, but not exponentially like in the north. I have been predicting this for a long time.
We should therefore not panic. If we can get through the lockdown properly, the plague will be wiped out by the end of the month.
Donald Trump Has Stake In Hydroxychloroquine Drugmaker: Report
President Donald Trump reportedly owns a stake in a company that produces hydroxychloroquine, the anti-malaria drug he has repeatedly touted as a coronavirus treatment even though his experts say there’s no strong evidence it works.
Trump “has a small personal financial interest” in Sanofi, the French drugmaker that makes Plaquenil, the brand-name version of hydroxychloroquine, The New York Times reported Monday.
In addition, Sanofi’s largest shareholders include a mutual fund company run by major Republican donor Ken Fisher, the paper said. Trump’s three family trusts, as of last year, each had investments in a mutual fund whose largest holding was Sanofi, according to the Times. Commerce Secretary Wilbur Ross also had ties to the drugmaker, the Times reported.
Trump’s “assertiveness” in promoting the drug contrary to the recommendation of top health experts “has raised questions about his motives,” the Times noted.(Quote)
I don’t know what Trump’s motivation is but there is good scientific reasoning behind the POSSIBLE benefits of Hydroxychloroquine. I did did some more research on the possible benefits of Hydoxychloroquine in the treatment of covid-19 related complications. I came across the following scientific paper. Readers can jump to the conclusion.
If the findings of this paper are correct then the implication is that going on a ventilator may be predictive of a poor outcome but ” chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress.”
Please google—Sermo Global Survey for details.
are U aware of any drug that does not have the potential for some side effect? Aspirin has done a fanstatic job for most people for donkey’s years but for some stomach bleed! Acetomenophin ie Tylenol, Paracetamol are excellent but mixed in with alcohol can potentially kill! Hence the saying for Emergencies / War “dont have horse ride cow”. Dr Daniel J Wallace, Rheumatologist, runs the largest such clinic in the USA has used HCQ formany years and says it is very safe and in 42 yrs has never had a patient hospitalised. Dr Marlow Hernandez, MDCano Hlth says he is using the protocol HCQ, zinc and Azithromicin with much success. Dr Stephen Smith, ID Specialist, using protocol great success. ditto DR Anthony Cardillo. Karen Whitsett , Dem Mich State Rep, had the virus for more than 19 days, had to fight with Mich authorities to attain permission to use as her idiot Gov Witmer Dem, was being an JennyASS, aka halfWit mer, her health plummeted and the Docs gave her the HCQ with other items as posted she had very positive results in HOURS! She is Afro Am Dem and she said “it saved my life.”
Many thousands of Docs using the protocl successfully.
Only real fools would buy Sanofi because of HCQ since it has been off patent for 50 years + and a malaria course costs US$20 . Maybe 1% of total sales at Sanofi and not very profitable.haha
@PingPong one does not need to know the POTUS motives and in simple fact the benefit of hydoxychloroquine is a decision between the patient and his/her doctor.
Personally I can’t believe that this man could be so crass and personally greedy to tout the drug because of his financial holdings…yes he is very self serving but this would be a lowest of low even for him…
This continued push of the chloroquine option is rather perplexing as it’s not a magic pill and as with all medicines it has its side effects ..let the matter be deliberated in the patient’s room and not at WH pressers…this is simply ridiculous !
@Money, what exactly are you trying here with “Only real fools would buy Sanofi because of HCQ since it has been off patent for 50 years + and a malaria course costs US$20 . Maybe 1% of total sales at Sanofi and not very profitable.haha”
That is disingenuous… and you know it. The issue is NOT the malaria treatment regimen but the astronomical spikes in sales for COVID patients if widespread approval is made.
As I said I really don’t believe that Trump could be so low but to see YOU hop on like speedy Gonzalez with a talking point already now gives me pause. SMH
Dribs pleeeez dont expose yourself. It is a very cheap drug it will not effect the EPS if sales triple. Pharmas make $$$$$$ on Patents! Anyway if U check he does not own Sanofi it is the usual Leftist / Dem / pressTITUTE proaganda!
As I have written before there is very reasonable scientific findings that hydroxychloroquine may relieve the symptoms of respiratory distress. Doctors should consider this and all medicines on the basis of scientific findings not on media approval or disapproval of someone who may tout a medicine. The North American media is so polarised that it has ceased to be informative in a positive way. Barbados has invested quite a lot in ventilators. The experience in North America as told to me by a A and E doctor in the USA, is that the overwhelming majority of patients die after going on ventilators and they die at such a rate that hospitals do not find ventilators in short supply.
de pedantic Dribbler April 7, 2020 4:39 PM #: “As I said I really don’t believe that Trump could be so low but to see YOU hop on like speedy Gonzalez with a talking point already now gives me pause. SMH”
@ de pedantic Dribbler
You handle these ‘Trumpsters’ really well.
I happen to come across the following YouTube video, while I was searching for old episodes of comedies. Ironically, it alleged to have been financed by some Republicans who are dissatisfied with FOX News coverage of the virus.
If you watch it, you’ll be amazed the level supposedly intelligent men and women would stoop just to keep in Trump’s ‘good books.’ It’s simply beyond reason.
Will the government please make mask wearing in public mandatory.
No wonder it keeps spreading so fast in all the various countries with the so called experts getting it wrong.
Doctor Faucu as recent s yesterday stated there isn’t enough evidence to support. As you know he is considered a guru in the area of infectious diseases.
We have three deaths so far.
How many have we had due to flu?
No one knows!!
No one seems interested.
Taiwan has few deaths, Singapore as well.
Both got hit by SARS.
What does SARS stand for?
Severe acute respiratory syndrome
Description
A contagious and sometimes fatal respiratory illness caused by a coronavirus.
SARS appeared in 2002 in China. It spread worldwide within a few months, though it was quickly contained. SARS is a virus transmitted through droplets that enter the air when someone with the disease coughs, sneezes, or talks. No known transmission has occurred since 2004.
Fever, dry cough, headache, muscle aches, and difficulty breathing are symptoms.
No treatment exists except supportive care.
Could it be that Taiwan and Singapore have a level of immunity not shared by other countries?
We may be shooting ourselves in the foot.
The symptoms of SARS are identical to those of COVID-19.
John go and listen to the press conference this morning.
@ Hal April 7, 2020 3:20 PM
It is a bit on the sleazy side but it publishes a lot of stuff others do not. I used to use the “Sun” and by the way, I noticed the ‘Sun” has interview videos on You Tube of very high quality. You must say a pray ( if you pray) for your arch enemy Boris.
@ Robert
You are moving up market, from the Sun to the Daily Mail. The editor of the Sun is ex DM, not one of my favourite former colleagues. I wish Boris well.
@ Hal April 7, 2020 3:45 PM
Some researchers say it is working. You are according to Trump ulterior motives. I do not think he has been touting it for that reason. As a matter of fact is the report correct? there is another report claiming that the administration did not heed a warning about the pandemic in late December early January. People forget that when the first case of the virus was detected and Trump ordered the ban on flights from China, he was deemed a racist. As a matter of Cuomo, Pelosi and the mayor of NYC all said it was a racist move and they all encouraged people to mingle ,claiming that the virus posed no harm.
Do you remember Ken Farnum? He has died aged 89.
these covid rants and raves on BU are most entertaining!
example Doctor Faucu as recent s yesterday stated there isn’t enough evidence to support. As you know he is considered a guru in the area of infectious diseases.
he is a guru in the area of infectious diseases. BUT NOT IN PHARMACOLOGY AND DURING THIS PANDEMIC HE HAS NOT BEEN ACTIVE AS A CLINICIAN TREATING PATIENTS
THE CLINICIANS WHO ARE ACTIVELY TREATING PATIENTS SAY THAT IT WORKS! THERE IS NOW CONSIDERABLE EMPIRICAL EVIDENCE THAT DEMONSTRATES THAT IT IT WORKS
PIN PONG IS MAKING SENSE!
As I have written before there is very reasonable scientific findings that hydroxychloroquine may relieve the symptoms of respiratory distress. Doctors should consider this and all medicines on the basis of scientific findings RATHER CLINICAL FINDINGS
THIS ONE IS CUTE TOO
This continued push of the chloroquine option is rather perplexing as it’s not a magic pill
ALL PILLS THAT WORK ARE MAGIC PILLS! EVEN ASPIRIN! ASPIRIN IS THE PROTOTYPE OF ALL NSAIDS.
and as with all medicines it has its side effects TELL US WHAT ARE THE SIDE EFFECTS SIR
THE FACT IS IT HAS A WIDE THERAPEUTIC INDEX…WHICH IS A FACTOR IN ITS FAVOR
MONEY BRAIN IS ALSO CORRECT ……..Many thousands of Docs using the protocl successfully. YES MANY THOUSAND CLINICIANS ARE USING THE DRUG SUCESSFULLY
BUT NO BU BRIMBLERS BARKERS BRAYERS ARE! UH LIE
BU BRIMBLERS BARKERS BRAYERS SHOULD ALL STICK TO WHAT THEY ARE GOOD AT AND LEFT OUT THE PHARMACOLOGY AND MICROBIOLOGY………….CAUSE WUNNA GENERALLY TALKING JUNK ALTHOUGH IT IS QUITE AMUSING AND HILARIOUS
SINCE VINCENT LIKES PING PONG’S CUT AND PASTE RE ” chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress, I WONDER IF HE COULD ENLIGHTEN US ON THE DEEP BIOCHEMISTRY AND CELL BIOLOGY MENTIONED .”
WHAT ARE orf1ab, ORF3a, and ORF10,?
HOW DOES heme form porphyrin? OR inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, AND HOW DOES THIS effectively relieve the symptoms of respiratory distress,
PLEASE ILLUMINATE AND ILLUCIDATE CAUSE I WANT TO LEARN
I WONT EVEN WORRY WITH THE Chartered Structural Engineer and President of Solutions Barbados WHO IS WAY WAY WAY OUT OF HIS LEAGUE HERE.
CONTINUE ALL CAUSE I GETTING BARE SPORT LISTENING TO WUNNA IN THE RUM SHOP LOL LOL
BU IS PUBLISHING EVERYBODY’S RUBBISH AND REFUSES TO PUBLISH THE POST OF A MAN WHO ACTUALLY KNOWS WHAT HE TALKING BOUT LOL
@ David April 7, 2020 5:12 PM
The only guru in science is the experimental results. This idea of the viral particles being spread by droplets is based on work done in the 1930’s as reported in one of those extract I have posted to BU. In science the experts do not like to be proven wrong. Science is really very ego-driven . .
Have you seen this Video…If you Cannot Buy Hydroxychloroquine buy Schweppes Tonic Water that has ton of Hydroxychloroquine and take it with high doses of Zinc … See the recommended quantity of Schweppes and Dosage of Zinc suggested by Doctor Eric Nepute.
https://www.facebook.com/drericnepute/videos/212203320055065/
Good, now return to eating your greasy turkey wings.
Steuspe
@Dr. Lucas
What do you suggest the medical fraternity does, go against the establishment?
GOOD! OF COURSE IT IS GOOD!
AND ACCURATE TOO!
JUST JOINING IN THE DISCUSSION, YOU NEVER KNOW HOW EXPRESSING YOUR VIEW MAY MAKE A DIFFERENCE. EVEN THOUGH THE TRUTH TENDS TO HURT
This is an opinion blog, people will share opinion some right, some wrong. Do what you do best.
Steupe
@ David April 7, 2020 6:11 PM
What I am saying is that it is the research scientists not the medical doctors one should be listening to. The research scientists are trained to do research work, most doctors know a lot about clinical symptoms( there are exception to the rule). The scientists are going to come up with new vaccines and so on. In this particular case they are already working to ascertain how the virus is spread The results seem to indicate a role for aerosols. The idea of droplets has been the Holy Grail” that is not supposed to be challenged. Science does not function that way. The more distinguished the person is pushing a line ,the harder it is for new ideas to come through.
RE This is an opinion blog, people will share opinion some right, some wrong. Do what you do best.
I ALWAYS DO!
I STICK TO WHAT I KNOW WELL AND I SEEK TO BE ACCURATE WHEN I OPINE AS I DID ABOVE
PEOPLE WHO RANT AND RAVE AND GIVE THEIR OPINIONS HERE THERE AND ANYWHERE OUGHT TO DO THE SAME.
BE ACCURATE! BE TRUTHFUL! AND ACCEPT WHEN YOU ARE CORRECTED
E.G IT IS A FACT HYDROQLOROQUINE HAS A WIDE THERAPEUTIC INDEX, WHICH IS ONE OF THE MOST DESIRABLE PARAMETERS OF ANY MEDICATION
THAT IS ONE OF THE REASONS WHY CLINICIANS CAN EMPLOY IT SUCESSFULLY ALL OVER THE WORLD IN THIS PANDEMIC
IT IS ACTING AS A “MAGIC PILL” BECAUSE IT IS HITTING THE RECEPTOR SITES OR TARGETS—-ANOTHER DESIRABLE PARAMETERS OF ANY MEDICATION
SO MY OPINION IS UNWELCOMED BECAUSE IT IS ACCURATE AND TRUE? LOL LOL
Private labs in Trinidad can start testing for COVID-19
(Trinidad Express) Private medical labs across Trinidad and Tobago are now being encouraged to begin performing tests for the COVID-19 coronavirus.
At a press conference in Port of Spain today, Health Minister Terrence Deyalsingh said that once the CARPHA-certified labs were equipped with the PCR (polymerase chain reaction) machines, they could proceed, once validated by CARPHA.
The PCR machine is the diagnostic tool used to detect the virus.
Deyalsingh said these private lab tests may see a rise in the number of confirmed cases.
He said that between TT$1,000 and TT$2.000 was being charged by one private lab to do a series of tests including for COVID-19.
He asked that private labs price their tests reasonably.
The Ministry of Health had held the position that private labs could not performed the tests since they were not certified by CARPHA.
CMO Dr Roshan Parasram said previously that there had been three positive tests coming from a private that proved to be incorrect.
Today, Parasram said that that he could not recommend a private lab to do the tests.
A list of validated labs will be published.
Deyalsingh said that the new regulations that came into effect today requires that the private labs, certified by CARPHA, has an obligation to report the findings of the test, be reported to the Chief Medical Officer and not the individual.
He said that under the regulations, any lab that did not conform would be fined TT$50,000 or six months in prison.
He said the decision as taken in order to ramp up testing, and create a national database on the virus.
NY Emergency Medicine Physician Claims COVID-19 Is An Oxygen Deprivation Disease Not Like Pneumonia
Published 04/05/2020
http://thejewishvoice.com/wp-content/uploads/2020/04/coronavirus-2-1000×666-1.jpg
Dr. Cameron Kyle-Sidell, an emergency medicine physician in Brooklyn and is affiliated with the Maimonides Medical Center, posted a very interesting video on you-tube. He is making the claim that COVID-19 is an oxygen deprivation disease , and in some cases the ventilators themselves, due to the high-pressure methods they are running, may be damaging the lungs and leading to widespread harm of patients & they should be operated in a different method. He is making the claim that COVID-19 is not a pneumonia-like disease at all.
In his video, he goes on to warn the world that the entire approach to treating COVID-19 may be incorrect, and that the disease is something completely different what is commonly accepted.
“In treating these patients, I have witnessed medical phenomena that just don’t make sense in the context of treating a disease that is supposed to be a viral pneumonia,” he explains.
“When we treat people with ARDS, we typically use ventilators to treat respiratory failure. But these patients’ muscles work fine. I fear that if we are using a false paradigm to treat a new disease, then the method that we program [into] the ventilator, one based on respiratory failure as opposed to oxygen failure, that this method being widely adopted … aims to increase pressure on the lungs in order to open them up, is actually doing more harm than good, and that the pressure we are providing to lungs, we may be providing to lungs that cannot take it. And that the ARDS that we are seeing, may be nothing more than lung injury caused by the ventilator”
He says that COVID-19 is like nothing seen before
Doc you have returned and your attitude has not changed, atall ..what a pity.
If you want to say that you speak accurately then pretty please don’t talk my remarks away from their context in an attempt to dismiss any relevance made…come now that’s beneath a man of your standing I would think.
My remark was contained in ONE sentence..offering one thought …one point as a whole NOT your funny separations.
It was very simple …the point was:… let the matter be deliberated in the patient’s room because all medicines have side effects and thus are truly never magic pills that make you well with a simple “poof” !
Nothing original or deep there of course but you still thought it necessary to disassemble a simple remark to do your attitude thing!
No cricket to watch one suspects…I was binging on the 2004 Champions trophy final and some other WI goodies recently!
Thought when you came back you would be ready to save our biological souls with great details… alas not!
Be good bro and if you can’t then just cut n paste accurately then nah!
I gone.
@Dr. Lucas
The question to you is how do you know the spokes people are not being advised by the researchers?
DR LUCAS
RE The research scientists are trained to do research work, most doctors know a lot about clinical symptoms( there are exception to the rule).
YOU ARE PARTIALLY CORRECT HERE FOR THE HISTORY OF MEDICINE AND ITS ADVANCEMENT IS REPLETE WITH THE DISCOVERIES OF CLINICIANS ——-ONE REASON WHY MANY DISEASES BARE THEIR NAMES… AS YOU HAVE CORRECTLY OPINED .there are exception to the rule).
RECALL THAT VACCINES IS A RATHER RECENT THING (CERCA 1950) AND IF I REMEMBER CORRECTLY BOTH SALK AND SABIN WERE CLINICIANS
PLEASE KINDLY NOTE THAT MANY CLINICIANS ARE ALSO RESEARCHERS
RECALL ALSO THAT THERAPEUTICS AS WE KNOW THEM TODAY STARTED TO COME TO THE FORE AROUND THE SAME TIME AND THAT SEVERAL CLINICIANS WERE AND CONTINUE TO BE INVOLVED IN THE RESEARCH
THEREOF.
KEEP ON KEEPING ON SIR!
DRIBBLER
YOU MUST LEARN NOT TO PLAY AT EVERY BALL!
WHAT I HAVE SAID ABOUT YOUR CONTRIBUTION IS ACCURATE AND IS SOUND DOCTRINE THAT CAN NOT BE REFUTED
WHAT I WROTE IN RESPONSE IS VERY SOUND BASIC PHARMACOLOGY
WHY DONT YOU ACCEPT IT AS SUCH AND LEARN THEREFROM
WHY NOT RESEARCH AND REPORT ON THE CONCEPT OF THERAPEUTIC INDEX…
This continued push of the chloroquine option is rather perplexing as it’s not a magic pill
ALL PILLS THAT WORK ARE MAGIC PILLS! EVEN ASPIRIN! ASPIRIN IS THE PROTOTYPE OF ALL NSAIDS.
and as with all medicines it has its side effects TELL US WHAT ARE THE SIDE EFFECTS SIR
THE FACT IS IT HAS A WIDE THERAPEUTIC INDEX…WHICH IS A FACTOR IN ITS FAVOR
MOREOVER YOUR ” point” THAT ” because all medicines have side effects and thus are truly never magic pills that make you well with a simple “poof” IS QUITE A VERY ERRONEOUS THOUGHT
AS A CLINICIAN I KNOW THAT TO BE FALSE FROM LONG EXPERIENCE WHETHER YOU BELIEVE THAT OR NOT
DRIBBLER
RE Thought when you came back you would be ready to save our biological souls with great details… alas not!
PLEASE KINDLY NOTE I AM NOT JESUS!
I CAN NOT HEAL THE SICK OR RAISE THE DEAD
IN MY CLINICAL EXPERIENCE I COULD DO ONLY THAT WHICH WAS CURRENT THERAPY AND HOPE FOR THE BEST, AS ALL DOCTORS OUGHT
AND THERE IS NOTHING WRONG WITH MY ATTITUDE——I JUST DONT SUFFER FOOLS GLADLY, AND I SPEAK PLAINLY WITHOUT MALICE.
I JUST LIKE HOOKING CUTTING PULLING DRIVING AND GENERALLY BEATING BAD BOWLING IN THE RUM SHOP.
Ok…I should correct my self as I said ALL…should have said “most”.
But why do YOU perceive that anyone making a point about something in your medical bailiwik is in some way attempting to dispute YOUR assertions on the science? That’s basically quite egotistical bro.
I am making a very basic fact of medicine which is that most medicines will carry a side effect that is not beneficial to the patient ..some or most of those are mild and then some can be quite dangerous to the patient…that’s why it’s vitally important for the doc to known his/her patient’s history details to ensure said patient is not killed with the medicines given to him/her to prolong life.
Even aspirin carries side effects as well.. so the issue was simply that the WH should not be touting …just simply highlight that promising results are being seen and move on…let the medicine and curative process proceed accordingly between doc and patient.
That is not questioning your clinical nous bro.
DRIBBLER
I should correct my self as I said ALL…should have said “most”. NO ALL DRUGS HAVE SIDE EFFECTS
YOUR ERROR IS THAT THEY ARE ” truly never magic pills that make you well with a simple “poof”
I UNDERSTAND THAT YOU HAVE PROBABLY NEVER SEEN AMINOPHYLINE WORK AS AN EXAMPLE
RE But why do YOU perceive that anyone making a point about something in your medical bailiwik is in some way attempting to dispute YOUR assertions on the science?
I AM NOT PERCEIVING OR ASSUMING ANYTHING SIR
I AM TELLING YOU THAT WHAT I SAY CAN NOT BE ACCURATELY REFUTED——-CAUSE I ENSURE THAT I AM ACCURATE WHEN PONTIFICATING IN MY AREAS OF EXPERTISE
RE so the issue was simply that the WH should not be touting …just simply highlight that promising results are being seen and move on…
THE WH HAS EVERY RIGHT TO PROMOTE A DRUG THAT THOUSANDS OF CLINICIANS WORLDWIDE HAVE FOUND TO BE EFFICACIOUS , I,E SINCE the medicine and curative process HAS BEEN DEMONSTRATED
RE That is not questioning your clinical nous bro.
I SUSPECT THAT YOU ALREADY KNOW VERY WELL THAT IT WOULD BE UNWISE TO DO SO
@John April 7, 2020 5:27 PM “Taiwan has few deaths, Singapore as well…Could it be that Taiwan and Singapore have a level of immunity not shared by other countries?”
Taiwan 376 cases, 5 deaths
Singapore 1481 cases, 6 deaths
Since theses places were battled SARS1 it is likely that they were better prepared to fight this one as well. I
David
April 7, 2020 5:33 PM
John go and listen to the press conference this morning.
++++++++++++++++++++++++++++++++++++
Done that.
What I am suggesting is the SARS-COVID-2 created an immunity in the countries it affected.
https://en.wikipedia.org/wiki/2002–2004_SARS_outbreak
It did not reach Barbados.
There were 29 countries affected by SARS-COVID-2 during the outbreak 18 years ago.
The major effects were felt in China, Hong Kong, Taiwan, Canada and Singapore.
Deaths so far this year vs the first SARS outbreak in these countries are as follows:
China – 349 vs 3331
Hong Kong – 299 vs 4
Taiwan – 73 vs 5
Canada – 43 vs 381
Singapore – 33 vs 6
Hong Kong, Taiwan and Singapore have not yet reached double figures.
Is there a herd immunity in these three countries?
How do we get a herd immunity if that is the case?
Are we shooting ourselves in the foot?
What happens when the next SARS-COVID-XX appears?
I understand I am being a little radical but should we not be paying attention to Sweden?
https://www.businessinsider.com/coronavirus-sweden-no-lockdown-test-thousands-deaths-expected-2020-4
Please note, I am not for one moment saying not to test with the object of quarantining or self isolating.
Hong Kong and Taiwan did take precautions early.
Hong Kong had its New Year celebrations canceled and Taiwan cut links on 23rd January with China.
Neither one had a critical mass of humanity from which the virus could propagate.
We are fortunate in that respect as well.
We can track unlike New York which was confronted by a deluge of cases.
There seems to be a link between deaths and lung damage whether by smoking, 911, coal mining, TB whatever.
Is it older people in general or older people with lung damage who succumb?
If it is our medical services may be spared.
“The symptoms of SARS are identical to those of COVID-19”
LOL, No quote from Rush, I thought Limbaugh said it was the common cold and it is given the number 19 because it is the 19th version
When a coronavirus affects humans it is categorized by how it affects the respiratory tract. This one is the second one discovered that causes the disease Severe Acute Respiratory Syndrome (SARS)
The scientific name for the virus is SARS-Cov-2, the first one was SARS-Cov-1
The WHO named the disease Covid-19 to differentiate it from the first one, that was simply called SARS
Covid stands for Corona virus disease
I am sure Taiwan, Hong Kong and Singapore do test and track relentlessly.
I am sure they also have quarantining and self isolation too.
What I am sure of too although I cannot find a reference for Singapore is that they took precautions early and prevented a mass of humanity flooding them.
The latest time for action was the last week in January 2020.
Taiwan took its action on January 23.
when you seek to use a drug or xenobiotic one should ideally first ascertain what is its mechanism of action
now for all the morons who are attacking DJT for promoting Hydroxychloroquine and chloroquine consider its mechanism of action to see how it works
THEN YOU MIGHT UNDERSTAND WHY IT WORKS
Mechanism of action of hydroxychloroquine
Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells (PDCs).
Hydroxychloroquine and chloroquine are weak bases and have a characteristic ‘deep’ volume of distribution and a half-life of around 50 days. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in inhibition of cytokine production and modulation of certain co-stimulatory molecules. These modes of action, together with the drug’s chemical properties, might explain the clinical efficacy and well-known adverse effects (such as retinopathy) of these drugs
Chloroquine and hydroxychloroquine increase pH within intracellular vacuoles and alter processes such as protein degradation by acidic hydrolases in the lysosome, assembly of macromolecules in the endosomes, and posttranslation modification of proteins in the Golgi apparatus. It is proposed that these compounds results from their interference with “antigen processing” in macrophages and other antigen-presenting cells. Acidic cytoplasmic compartments are required for the antigenic protein to be digested and for the peptides to assemble with the alpha and beta chains of MHC class II proteins.
As a result, they diminish the formation of peptide-MHC protein complexes required to stimulate CD4+ T cells and result in down-regulation of the immune response against autoantigenic peptides. this mechanism is well suited to complement other compounds in combination drug therapy.
Coronaviruses are a family of viruses that range from the common cold to MERS coronavirus, which is Middle East Respiratory Syndrome coronavirus and SARs, Severe acute respiratory syndrome coronavirus.
I know someone who tested positive for a corona virus in the USA but it was a cold.
That was late December or early January.
The doctors wanted to explain the cause of a fever so wanted to eliminate flu, which they did.
Turned out there was another cause.
“now for all the morons who are attacking DJT for promoting Hydroxychloroquine and chloroquine consider its mechanism of action to see how it works”
Good info, I am sure Trump used this as his basis too.
Instead of trying so hard to defend Trump every chance you get, just provide the facts and stop pretending you know Trumps mind.
The MERS outbreak mainly affected Saudi Arabia, South Korea, UAE, Jordan and Quatar.
This year so far, UAE has 12 deaths, Qatar has 6 deaths, Jordan has 6 and South Korea 200.
Most people, including me, doubt China’s numbers.
However, they may be explicable.
The blogmaster invites you to join the discussion.